1.
Org Biomol Chem
; 10(24): 4692-5, 2012 Jun 28.
Artigo
em Inglês
| MEDLINE
| ID: mdl-22596019
RESUMO
A catalytic version of the Rabe electrophilic amination is presented. This kind of reaction was originally employed in 1918 in a key step for the conversion of quinotoxine to quinine. Ketones and α-substituted aldehydes give the corresponding α-aminated carbonyl compounds in moderate yield. α,α-Unsubstituted aldehydes give rise to amino ketones via a novel rearrangement.